Paratyphoid fever


Paratyphoid fever, often overshadowed by its close cousin typhoid fever, is a bacterial illness that still poses a significant threat to global health, particularly in resource-limited settings. Caused by the bacteria Salmonella Paratyphi A, B, or C, it shares many similarities with typhoid fever, but also holds distinct characteristics in terms of epidemiology, clinical presentation, and treatment. In this article, we’ll delve deep into the world of paratyphoid fever, exploring its causes, symptoms, diagnosis, treatment, and preventive measures.

The Bacterial Culprits:

The main culprits behind paratyphoid fever are three serovars of Salmonella enterica:

  • Salmonella Paratyphi A: The most common culprit, responsible for roughly 80% of paratyphoid cases globally.
  • Salmonella Paratyphi B: Less common than A, but prevalent in Southeast Asia and Latin America.
  • Salmonella Paratyphi C: The rarest of the three, often causing sporadic outbreaks or isolated cases.

These bacteria reside in the intestines of infected individuals and are excreted through feces. Contaminated water and food become the transmission vehicles, making poor sanitation and hygiene key risk factors for contracting paratyphoid fever.

A Global Traveler:

Paratyphoid fever has a worldwide distribution, but the burden of the disease is concentrated in low- and middle-income countries with inadequate sanitation and water infrastructure. South Asia, Southeast Asia, Latin America, and Africa bear the brunt of the disease, with children under five years old being the most vulnerable group.

Symptoms: A Deceptive Onset:

Paratyphoid fever’s symptoms can be insidious and develop gradually, making early diagnosis challenging. The initial phase is often marked by:

  • Fever: A gradual rise in body temperature, reaching as high as 104°F (40°C) within days. The fever pattern can be characteristic, with lower temperatures in the morning and higher spikes in the evening.
  • Headache: A persistent, dull headache that can be accompanied by dizziness.
  • Malaise: A general feeling of fatigue and weakness, hindering daily activities.
  • Gastrointestinal Issues: Constipation, abdominal pain, and diarrhea, although less common than with typhoid fever.
  • Loss of Appetite: A significant decrease in appetite, leading to weight loss.

As the disease progresses, additional symptoms may emerge:

  • Rose-colored Rash: A characteristic rash of flat, pink spots may appear on the chest and abdomen.
  • Altered Mental State: Confusion, delirium, and even coma can occur in severe cases.
  • Enlarged Spleen and Liver: Physical examination may reveal these findings.

Diagnosing the Deceiver:

Accurate diagnosis of paratyphoid fever is crucial for prompt and effective treatment. Blood cultures remain the gold standard, but their results can take time. Rapid diagnostic tests, such as TyphiDot and Widal tests, offer quicker options but may lack specificity. Stool cultures can also be helpful in some cases.

Combating the Bacterial Onslaught:

Antibiotics are the mainstay of paratyphoid fever treatment. Ciprofloxacin and other fluoroquinolones are typically the first-line choices. However, antibiotic resistance is a growing concern, necessitating careful selection of medication based on local resistance patterns. In severe cases, hospitalization and supportive care may be necessary.

Prevention: The Key to Breaking the Cycle:

Safe water, sanitation, and hygiene practices are the cornerstones of paratyphoid fever prevention. Access to clean drinking water, proper sewage disposal, and handwashing with soap are essential. Vaccination with the Typhoid Conjugate Vaccine (TCV) can also offer significant protection against both typhoid and paratyphoid fevers.

Beyond the Individual:

The fight against paratyphoid fever requires a multi-pronged approach beyond individual prevention. Strengthening healthcare systems, improving water and sanitation infrastructure, promoting hygiene education, and conducting ongoing surveillance are crucial to reducing the disease burden and protecting vulnerable communities.

A Call to Action:

While paratyphoid fever may not garner the same attention as other global health threats, its impact on individuals and communities around the world is undeniable. Raising awareness, investing in prevention and control measures, and fostering international cooperation are vital steps towards mitigating the burden of this potentially life-threatening disease.


  • Paratyphoid fever is a bacterial illness caused by Salmonella Paratyphi A, B, or C.
  • It shares similarities with typhoid fever but has distinct characteristics.
  • Poor sanitation and hygiene are major risk factors for infection.
  • Early diagnosis and prompt treatment are crucial for preventing complications.
  • Vaccination with TCV offers significant protection.
  • Addressing the social determinants of health and